Managing Sustainable Drug Spend: 5 Trends Reshaping Pharmacy Benefits in 2025

The US health care market faces transformative changes in 2025, as biosimilars, GLP-1s, and new pharmacy economics reshape how benefit managers balance innovation with affordability.

Health care within the US is entering a transformative period. Medical spending is projected to reach $485 billion in 2025, according to IQVIA.1 Health spend is projected to increase an average of 4% to 7% a year, with a 13.3% increase in specialty drug trend according to the annual Segal survey.2 This growth comes while traditional boundaries between wholesalers, manufacturers, pharmacy benefit managers (PBMs), payers, and providers are increasingly blurred. We are seeing complicated ownership and business relationships that comingle buying organizations, manufacturers, PBMs and health plans. This creates both challenges and opportunities for benefit administrators and payers.

Within this landscape, trends around biosimilars, glucagon-like peptide-1 (GLP-1) drugs, and other medications will influence cost changes in the marketplace. Unique breakthrough therapies and new combination formulations will give patients novel treatment options, often at a higher cost. And, as a new administration enters in 2025, the potential for policy recommendations will signal changes to the industry.

With all of this in the air, a few trends stand out to have the biggest impact on benefit administrators and payers in the coming year.

REFERENCES
  1. The Use of Medicines in the US 2024: Usage and Spending Trends and Outlook to 2028. IQVIA. May 7, 2024. Accessed January 22, 2025. https://www.iqvia.com/insights/the-iqvia-institute/reports-and-publications/reports/the-use-of-medicines-in-the-us-2024
  2. What Are the Projected 2025 Health Plan Cost Trends? Segal. September 18, 2024. Accessed January 22, 2025. https://www.segalco.com/consulting-insights/2025-health-plan-cost-trend-survey
MORE ABOUT Sharon Faust, PharmD, MBA, CSP

Sharon Faust is the Chief Pharmacy Officer at Navitus Health Solutions. She oversees Health Strategies, Provider Services and Lumicera Health Services. She is a licensed pharmacist in Wisconsin and is on the Board of Directors for the National Association of Specialty Pharmacy and the Drug Selection Advisory Committee for CivicaScript®. In 2023, she was awarded the top 50 most influential leaders in Pharmacy award presented by the Pharmacy Podcast network.

Stay Informed and Connected

Receive expert insights, healthcare tips, and important updates on pharmacy benefits, drug recalls, and more—straight to your inbox.

Navigating with a trusted partner

Now Available: 9th Annual Drug Trend Report

Our Drug Trend Report provides a clear view of the trends shaping pharmacy benefits today, along with strategies that are delivering real savings without compromising care.

Related blogs

Navigating Healthcare and Improving Outcomes

PBM 101: Understanding Spread Pricing and Its Impact on Plan Costs 

PBM 101: Understanding Spread Pricing and Its Impact on Plan Costs 

There is no shortage of questions surrounding pharmacy benefit business models, especially when medication costs continue to rise. One major area of concern centers on a practice that often goes unnoticed or not understood: spread pricing.  …

Part D Star Ratings Adherence Measures: Enabling Strategic and Focused Support for High-risk Beneficiaries Through the Reporting and Intervention for Stars Excellence (RISE) Program

Part D Star Ratings Adherence Measures: Enabling Strategic and Focused Support for High-risk Beneficiaries Through the Reporting and Intervention for Stars Excellence (RISE) Program

Authors: Wenxuan Cai, PharmD, PhD; Amanda Lee, PharmD; Caitlin Albrecht, PharmD; Maria Basak, CPhT; Casey Herlache; Capriana Hadel, MBA Executive Summary Adherence to key medication classes is a critical metric for evaluating health plan quality and continuous…

PBM 101: How to Evaluate Your PBM

PBM 101: How to Evaluate Your PBM

Choosing a pharmacy benefit manager (PBM) isn’t just about managing prescription drug costs – it’s about ensuring your PBM operates in a way that aligns with your financial, operational and philosophical goals. A truly aligned PBM works toward the same…

Introducing NavitusClear with Costco® Cost Plus Model

Introducing NavitusClear with Costco® Cost Plus Model

NavitusClear is our designation awarded to partners that exemplify the level of transparency in drug pricing we believe should be the industry norm. This solution reflects the shared commitment between Navitus and Costco to address rising drug costs…

PBM 101: Understanding Transparency for Better Pharmacy Benefits

PBM 101: Understanding Transparency for Better Pharmacy Benefits

When it comes to pharmacy benefit managers (PBMs), the word “transparency” gets thrown around a lot. It’s frequently promised, widely discussed and inconsistently delivered.  …

Legal Ease: Key Legislative & Regulatory Updates Impacting Plan Sponsors in 2025

Legal Ease: Key Legislative & Regulatory Updates Impacting Plan Sponsors in 2025

In this overview of our national Legal Ease webinar event, we highlight key federal and state developments shaping the conversation around PBM reform – and what they mean for your clients.  …

Navigating the Drug Supply Chain: What You Need to Know

Navigating the Drug Supply Chain: What You Need to Know

Before a prescription ever reaches a pharmacy counter, it has already moved through a complex ecosystem known as the drug supply chain. From manufacturers and wholesalers to pharmacy benefit managers (PBMs) and pharmacies, each entity plays a role in…

Real-world Data Demonstrates Successful Transitions from Humira to Biosimilars

Real-world Data Demonstrates Successful Transitions from Humira to Biosimilars

Authors: Justin Arzt, PharmD; Agata Siwak, PharmD, MSBA; Marnie Wickizer, PharmD, AE-C, CDCES; Ryan Schmidt, PharmD; Robert Topp, RN, PhD; Matt Hustad, PharmD All authors are employees of Navitus Health Solutions. Abstract Adalimumab biosimilar adoption…

PBM 101: Why the Model Matters

PBM 101: Why the Model Matters

In the pharmaceutical and healthcare industry, pharmacy benefit managers (PBMs) are conduits of expertise, analytics and savings opportunities, poised to deliver exceptional health care while driving down costs. They coordinate between drug manufacturers,…

previous arrow
next arrow